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in a review of studies, published in, researchers saw a useful and effective role for marijuana in treating migraine, but there are not enough studies on using cbd oil specifically yet. learn all about the latest research on cbd oil and migraine. get the facts on benefits, side effects, cbd oil’ s legal status, and more. cbd oil has potential as a safe, natural treatment for migraine. several studies have linked cbd oil with pain free relieving properties, and also documented its safety. this prompts a lot of migraine sufferers to try cbd oil for migraine relief, but due to regulations and changing laws in your state, you may not have had the chance try it.